Improving blood donor screening by nucleic acid technology (NAT)
Identifieur interne : 002800 ( Main/Exploration ); précédent : 002799; suivant : 002801Improving blood donor screening by nucleic acid technology (NAT)
Auteurs : M. Schmidt [Allemagne] ; E. Seifried [Allemagne]Source :
- ISBT Science Series [ 1751-2816 ] ; 2010-07.
English descriptors
- Teeft :
- Acid screening, Analytical sensitivity, Apheresis platelets, Assay, Bacterial concentration, Bacterial contamination, Bacterial detection, Bacterial screening, Blood banks, Blood collections, Blood components, Blood donation, Blood donations, Blood donor screening, Blood donor screening programmes, Blood donors, Blood products, Blood safety, Blood transfusion, Blood transfusions, Broad range, Chikungunya virus, Clin, Clin microbiol, Clinical symptoms, Combo test, Culture methods, Detection systems, Diagnostic window period, Different countries, Donation, Donor, Early infection period, Enrichment centrifugation, Ethidium bromide, Extraction method, General screening, Hepatitis, Higher risk, Human virus, Human virus type, Hybridization probes, Immune system, Inactivation, Indian ocean, Individual donation, Individual donations, Infection, International society, Isbt, Isbt science series, Johann wolfgang goethe university, Journal compilation, Late sample collection, Many countries, Maximum number, Maximum pool size, Microbiol, Molecular beacon, Molecular beacons, Negative screening results, Nucleic, Nucleic acid technology, Nucleic acid testing, Other hand, Pathogen, Pathogen inactivation, Pathogen reduction, Plasma products, Platelet, Platelet products, Polymerase, Polymerase chain reaction, Pool size, Primer, Probe, Probe binding regions, Rapid detection, Residual, Residual risk, Respiratory syndrome coronavirus, Reunion island, Roth, Sample tubes, Schmidt, Screening, Screening assays, Screening systems, Seifried, Serological systems, Special circumstances, Special risks, Special situation, Tigris ultrio, Transfus, Transfus apher, Transfusion, Transfusion medicine, Ttis, Ultraviolet light, Uorescence, Virol methods, Virus, Virus infections hepatitis, Virus load, West africa, West nile virus, Whole blood, Window period, Yersinia enterocolitica.
Abstract
The description of the ABO blood group system by Landsteiner and coworkers marked a sea change in making blood transfusions feasible and safe for a broad range of indications. Nevertheless, with an increase in blood transfusions, side‐effects such as transfusion‐transmitted infections (TTIs) became more and more important. A major challenge in transfusion medicine was (and is) to develop screening assays with maximum analytical sensitivity and analytical specificity to reduce the diagnostic window period as much as possible. Until the late 1990s, blood screening for TTIs depended entirely on serological assays. Except for HBV, where the virus can be detected using HBs‐antigen assays, tests for the detection of other TTIs relied almost exclusively on antibody detection. These tests, however, are associated with a relatively long diagnostic window period because they detect the response of the immune system to an infection.
Url:
DOI: 10.1111/j.1751-2824.2010.01410.x
Affiliations:
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Schmidt</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Transfusion Medicine and Immunohematology, German Red Cross, Johann Wolfgang Goethe University, Frankfurt</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Seifried, E" sort="Seifried, E" uniqKey="Seifried E" first="E." last="Seifried">E. Seifried</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Transfusion Medicine and Immunohematology, German Red Cross, Johann Wolfgang Goethe University, Frankfurt</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">ISBT Science Series</title><title level="j" type="sub">XXXIst International Congress of the ISBT</title><title level="j" type="alt">ISBT SCIENCE SERIES</title><idno type="ISSN">1751-2816</idno><idno type="eISSN">1751-2824</idno><imprint><biblScope unit="vol">5</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="219">219</biblScope><biblScope unit="page" to="229">229</biblScope><biblScope unit="page-count">11</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-07">2010-07</date></imprint><idno type="ISSN">1751-2816</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1751-2816</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acid screening</term><term>Analytical sensitivity</term><term>Apheresis platelets</term><term>Assay</term><term>Bacterial concentration</term><term>Bacterial contamination</term><term>Bacterial detection</term><term>Bacterial screening</term><term>Blood banks</term><term>Blood collections</term><term>Blood components</term><term>Blood donation</term><term>Blood donations</term><term>Blood donor screening</term><term>Blood donor screening programmes</term><term>Blood donors</term><term>Blood products</term><term>Blood safety</term><term>Blood transfusion</term><term>Blood transfusions</term><term>Broad range</term><term>Chikungunya virus</term><term>Clin</term><term>Clin microbiol</term><term>Clinical symptoms</term><term>Combo test</term><term>Culture methods</term><term>Detection systems</term><term>Diagnostic window period</term><term>Different countries</term><term>Donation</term><term>Donor</term><term>Early infection period</term><term>Enrichment centrifugation</term><term>Ethidium bromide</term><term>Extraction method</term><term>General screening</term><term>Hepatitis</term><term>Higher risk</term><term>Human virus</term><term>Human virus type</term><term>Hybridization probes</term><term>Immune system</term><term>Inactivation</term><term>Indian ocean</term><term>Individual donation</term><term>Individual donations</term><term>Infection</term><term>International society</term><term>Isbt</term><term>Isbt science series</term><term>Johann wolfgang goethe university</term><term>Journal compilation</term><term>Late sample collection</term><term>Many countries</term><term>Maximum number</term><term>Maximum pool size</term><term>Microbiol</term><term>Molecular beacon</term><term>Molecular beacons</term><term>Negative screening results</term><term>Nucleic</term><term>Nucleic acid technology</term><term>Nucleic acid testing</term><term>Other hand</term><term>Pathogen</term><term>Pathogen inactivation</term><term>Pathogen reduction</term><term>Plasma products</term><term>Platelet</term><term>Platelet products</term><term>Polymerase</term><term>Polymerase chain reaction</term><term>Pool size</term><term>Primer</term><term>Probe</term><term>Probe binding regions</term><term>Rapid detection</term><term>Residual</term><term>Residual risk</term><term>Respiratory syndrome coronavirus</term><term>Reunion island</term><term>Roth</term><term>Sample tubes</term><term>Schmidt</term><term>Screening</term><term>Screening assays</term><term>Screening systems</term><term>Seifried</term><term>Serological systems</term><term>Special circumstances</term><term>Special risks</term><term>Special situation</term><term>Tigris ultrio</term><term>Transfus</term><term>Transfus apher</term><term>Transfusion</term><term>Transfusion medicine</term><term>Ttis</term><term>Ultraviolet light</term><term>Uorescence</term><term>Virol methods</term><term>Virus</term><term>Virus infections hepatitis</term><term>Virus load</term><term>West africa</term><term>West nile virus</term><term>Whole blood</term><term>Window period</term><term>Yersinia enterocolitica</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The description of the ABO blood group system by Landsteiner and coworkers marked a sea change in making blood transfusions feasible and safe for a broad range of indications. Nevertheless, with an increase in blood transfusions, side‐effects such as transfusion‐transmitted infections (TTIs) became more and more important. A major challenge in transfusion medicine was (and is) to develop screening assays with maximum analytical sensitivity and analytical specificity to reduce the diagnostic window period as much as possible. Until the late 1990s, blood screening for TTIs depended entirely on serological assays. Except for HBV, where the virus can be detected using HBs‐antigen assays, tests for the detection of other TTIs relied almost exclusively on antibody detection. These tests, however, are associated with a relatively long diagnostic window period because they detect the response of the immune system to an infection.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Darmstadt</li><li>Hesse (Land)</li></region><settlement><li>Francfort-sur-le-Main</li></settlement></list><tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Schmidt, M" sort="Schmidt, M" uniqKey="Schmidt M" first="M." last="Schmidt">M. Schmidt</name></region><name sortKey="Seifried, E" sort="Seifried, E" uniqKey="Seifried E" first="E." last="Seifried">E. Seifried</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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